Abstract
Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory arthritis in children. Mean platelet volume (MPV) is an indicator of platelet size and has been investigated as an inflammation marker in several diseases. This study was designed to investigate the MPV values in patients with JIA and healthy subjects, and determine the correlation between MPV, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). The hospital records of a total of 40 children with JIA, diagnosed using the International League of Associations for Rheumatology (ILAR) criteria, and 40 healthy controls were enrolled into the study. White blood cell count (WBC), platelet count, CRP, ESR, and MPV levels were retrospectively recorded. Children with JIA had significantly higher MPV values (8.28±1.12 fL) compared to the control group (7.53±1.07 fL) (p=0.003). Significant correlations were found between MPV, ESR, and CRP in the JIA group (r=0.676, p 0.05). Our results suggest that MPV levels may be a useful marker of inflammation and prognostic factor for atherosclerosis risk in pediatric JIA patients.
Highlights
Juvenile idiopathic arthritis (JIA) is one of the most common pediatric rheumatologic disorders, which is caused by a combination of genetic and environmental factors with an onset before the age of 16 years that lasts for at least 6 weeks [1]
A total of 40 patients diagnosed with JIA (21 girls, 19 boys), and 40 healthy controls (19 girls, 21 boys) with the same age range were included in the study
In patients with JIA, the observation of chronic inflammatory processes have continued to increase over the years with an ongoing subclinical inflammation
Summary
Juvenile idiopathic arthritis (JIA) is one of the most common pediatric rheumatologic disorders, which is caused by a combination of genetic and environmental factors with an onset before the age of 16 years that lasts for at least 6 weeks [1]. All subtypes of JIA are known to be associated with chronic joint inflammation and the elevated concentrations of some biomarkers, such as CRP and ESR may reflect this process. ESR can be affected by different factors unrelated to inflammation, including age, renal failure, and anemia. Rheumatoid inflammation may lead to systemic manifestations, including accelerated atherosclerosis [3]. Since continuous systemic inflammation is known to accelerate atherosclerosis, patients with JIA and especially those with permanent inflammation may be at elevated risk of cardiovascular disease (CVD) [4]
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