Abstract
The prevalence of juvenile idiopathic arthritis (JIA) in Ukrainian children’s population is 4.1 per 10 000 and the total number of children with JIA is about 3000. JIA couldn’t be considered as a benign disease, because very often it results in a sustainable disability. Previously was shown, that early diagnostic and treatment lead to better results. TNF is a key proinflammatory cytokine in the pathogenesis of oligoarthicular and polyarthicular forms of JIA. TNF-inhibition can prevent irreversible structural joint damage. In children with methotrexate failure the after treatment with biologic agents reduces the number of disease flares by 54%. Adalimumab, the anti-TNF-alpha recombinant human monoclonal antibody, recently had been approved in Ukraine for the treatment of polyarthicular juvenil arthritis in children and was included to the state JIA treatment funding programme.
Highlights
The prevalence of juvenile idiopathic arthritis (JIA) in Ukrainian children’s population is 4.1 per 10 000 and the total number of children with JIA is about 3000
RF-negative and persistent oligoarthritis (48.2% and 22.8%, respectively). 7 children (8.8%) were HLA B27 positive: 6 boys and 1 girl. 7 of all patients were treated with adalimumab and DMARDs
All children on adalimumab were boys with age from 9 to 16 years. 6 children had Pediatrics, P.L.Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine polyarthicular course of JIA, 1 – systemic arthritis
Summary
The prevalence of juvenile idiopathic arthritis (JIA) in Ukrainian children’s population is 4.1 per 10 000 and the total number of children with JIA is about 3000. JIA couldn’t be considered as a benign disease, because very often it results in a sustainable disability. Was shown, that early diagnostic and treatment lead to better results. TNF is a key proinflammatory cytokine in the pathogenesis of oligoarthicular and polyarthicular forms of JIA. TNF-inhibition can prevent irreversible structural joint damage. In children with methotrexate failure the after treatment with biologic agents reduces the number of disease flares by 54%. Adalimumab, the anti-TNFalpha recombinant human monoclonal antibody, recently had been approved in Ukraine for the treatment of polyarthicular juvenil arthritis in children and was included to the state JIA treatment funding programme
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