Abstract
In this work, the stability of nanojars of the formula [CO3⊂{Cu(OH)(Rpz)}n]2− (pz = pyrazole derivative; R = H, 4-(CH3OCH2CH2O) or 4-(CH3(OCH2CH2)3O); n = 27, 29, 31) in the presence of biological molecules found in human body fluids was investigated using electrospray ionization mass spectrometry (with small biomolecules) and UV–vis spectroscopy (with proteins and serum). Lipids (triglycerides and cholesterol), glucose, urea, uric acid, creatine, creatinine, amino acids (glycine, alanine, glutamic acid, tyrosine), bilirubin, adenine, ascorbic acid, albumin, γ-globulins and fibrinogen display varying degrees of reactivity towards nanojars, ranging from no interaction to substitution of nanojars by pyrazolate ligand replacement to complete nanojar breakdown. Nanojars appear to be overall stable in pure human serum solutions (pH 8.0).
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