Abstract

Purpose: Building a list of contraindicated drug interactions and evaluating the initial results of applying information technology to prevent contraindicated drug interactions in prescriptions at the Military hospital 7. Subjects and Methods: A retrospective, descriptive study evaluated 158,213 prescriptions before integrating the drug interaction warning utility and 18,222 prescriptions after integrating the drug interaction at the Military hospital 7. Results: Successfully built and integrated 82 pairs of contraindicated drug interactions in Hospital information system (HIS) software, including 54 pairs with contraindicated drug interactions in combination and 28 pairs of contraindicated drug interactions in specific clinical contexts. In 158,213 prescriptions before integrating the drug interaction warning utility, 45 prescriptions with contraindicated drug interactions were identified (including nine prescriptions with contraindicated drug interactions in combination, with two pairs of drug interactions, and 36 prescriptions with contraindicated drug interactions in specific clinical contexts, with seven pairs of drug interactions). In 18,222 prescriptions after integrating real-time contraindicated drug interaction warnings on HIS software, no prescriptions with contraindicated drug interactions detected. Conclusions: The initial application of information technology has improved a positive effect in preventing contraindicated drug interactions in prescriptions at Military hospital 7.

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