EVALUATION OF THE INHERITANCE OF COPY NUMBER VARIATIONS (CNVs) IN THE EMBRYOS WHEN THE SAME CNV PRESENTS IN MORE THAN ONE EMBRYO AFTER PGT-A FROM IVF CYCLES

Abstract

CNV involves both duplications and deletions of DNA sequences, which may cause human diseases. Some CNVs can be identified using targeted next generation sequencing-based preimplantation genetic testing for aneuploidy (PGTseqA). When the same patterns of CNVs are observed in multiple embryos, one of the parents may carry the CNV. In this study, we requested follow-up parental testing to confirm whether the same CNVs presenting in more than one embryo are inherited.