Abstract
Pharmaceutical care is a professional practice seeking the responsible provision of drug therapy by identifying, resolving, and preventing Drug-Related Problems (DRP). The study aims to describe and evaluate the impact of pharmaceutical care given to patients being treated for tuberculosis (TB). Study concurrent, longitudinal, prospective conducted during pharmaceutical care in the TB outpatient clinic, Clinical Hospital, Federal University of Minas Gerais during the period August 2009 to July 2012. The Pharmacotherapy Workup proposed by Cipolle et al. (2004) was used. Statistical analyses were performed by X2 or Fisher exact test, as appropriate. A total of 62 patients were followed up, and 128 drug-related problems (DRP) were identified: 69.5% related to safety, 13.3% to effectiveness, 12.5% to indication, and 4.7% to treatment adherence, and 62.1% of the DRP were resolved. A total of 115 pharmaceutical interventions were performed. The impact of pharmaceutical care was satisfactory for 73.9% of patients with a resolution rate of 77%. There was a greater impact on pharmaceutical care (index ≥ 0.50) for those patients who were not smokers (p <0.05). The impact of pharmaceutical care was important, so the pharmacist should work alongside the multidisciplinary team to monitor treatment and perform interventions.
Highlights
Pharmaceutical care is a professional practice seeking the responsible provision of drug therapy by identifying, resolving, and preventing Drug-Related Problems (DRP)
The majority of TB cases occurred in patients of working age, which corroborates the findings of other authors (Breen et al 2006, Vieira and Gomes 2008, Ferreira et al 2013)
The age range of patients predominated in the study is over forty years old and is a predictive factor for the development of adverse reactions (Conde and Souza 2009, Brasil 2011)
Summary
Pharmaceutical care is a professional practice seeking the responsible provision of drug therapy by identifying, resolving, and preventing Drug-Related Problems (DRP). TB treatment is conducted over a long period of time and requires the use of various pills, which often have drug interactions and adverse reactions that can hamper adherence (WHO 2016) These effects may be minor and include mainly nausea, vomiting, abdominal pain, epigastric pain, itching, joint pain, peripheral neuritis, changes in appetite, sleep disorders, anxiety, and hyperuricemia. These reactions do not require suspension of the use of TB drugs but rather the introduction of other drugs to reduce said reactions. Major effects include the appearance of rash, seizures, jaundice, and optic neuritis, among other symptoms, in which case, generally, the cessation of drug therapy is necessary (Vieira and Gomes 2008, Arbex et al 2010, Maciel et al 2010, Brasil 2011, Ferreira et al 2013, Silva et al 2017)
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