EVALUATION OF THE IMPACT OF GREEN TEA PLANT EXTRACT ON INTESTINAL ABSORPTION OF ASPIRIN USING EVERTED SAC TECHNIQUE

Abstract

In vivo Absorption investigations are time-consuming and expensive in order to find the best medication formulation.Models were employed to research drug permeability and dissolution in order to streamline the search for arecommended formulation. One example of an in vitro model is the use of a goat intestinal section (sac) to assess theabsorption of related drugs prior to formulation and clinical investigations. The investigation of excipient and additiveeffects on drug permeability is an intriguing use of this method. In this paper, the impact of epigallocatechin -3-gallate(EGCG), on the intestinal penetration of acetyl salicylic acid was investigated. When Aspirin was kept with green plantextract, the concentration of absorbed Aspirin was 12, 32 ,45, 49 and 51μg/ml after 15, 30, 45, 60 and 75 minrespectively; whereas 14 ,16 ,17 ,18 and 23 μg/ml of Aspirin was absorbed when kept alone. The study clearly showedthat the green tea extract enhances the absorption of Aspirin from goat intestine and this absorption enhancement activityof the plant is due to polyphenolic content, presence of polyphenols like catechins and epicatechins.