Abstract
BackgroundYigan mingmu oral liquid (YGMM) is a herbal medicine based on a famous Chinese herbal formula that has been used for sore eyes for more than 400 years. Eye health is closely associated with the liver based on TCM. This study aimed to investigate the hepatoprotective effect of YGMM against acute liver injury induced by alcohol in rats.MethodsExperimental rats were administered with silymarin and YGMM through the gastric gavage during the entire experiment. Starting from the 11th day, the rats were administered orally with 14 ml/kg Red Star Erguotou Liquor, a popular brand, at 4 h after the dose of silymarin (100 mg/kg) and YGMM (1, 2.5 and 5 ml/kg in low, middle and high dosage group, respectively) once a day for 4 weeks except for the rats in the normal group. Biochemical parameters, including ALT, AST, TB, TG, T-SOD, GSH, and MDA were detected to evaluate the protective effect of YGMM. Pathological changes were observed through histopathological examination.ResultsTreatment with YGMM exhibited a significant protective effect by reversing the biochemical parameters (ALT, AST, TB, TG, and GSH) and histopathological changes. Histopathological examination by Oil Red O Staining Solution showed that lipid droplets were significantly reduced in the silymarin and YGMM groups (p < 0.001) when compared to alcohol group.ConclusionsYGMM exhibits a significant hepatoprotective activity against acute liver injury induced by alcohol in rats.
Highlights
Yigan mingmu oral liquid (YGMM) is a herbal medicine based on a famous Chinese herbal formula that has been used for sore eyes for more than 400 years
Yigan mingmu oral liquid (YGMM) is a herbal medicine based on a famous Chinese herbal formula composed of 12 crude herbs: Rehmanniae Radix Preparata (Shudihuang), Mo et al BMC Complementary Medicine and Therapies (2020) 20:32
YGMM is based on Siwu decoction, an ancient formula first recorded in the secret formulary for traumatology and fracture taught by immortal in the Tang Dynasty and was used to treat trauma and extravasated blood
Summary
Yigan mingmu oral liquid (YGMM) is a herbal medicine based on a famous Chinese herbal formula that has been used for sore eyes for more than 400 years. Angelicae Sinensis Radix (Danggui), Lycii Fructus (Gouqizi), Paeoniae Radix Alba (Baishao), Ophiopogonis Radix (Maidong), Chrysanthemi Flos (Juhua), Anemones Altaicae Rhizoma (Jiujiechangpu), Polygonati Odorati Rhizoma (Yuzhu), Chuanxiong Rhizoma (Chuanxiong), Citri Reticulatae Pericarpium (Chenpi), Cassiae Semen (Juemingzi), and Bupleuri Radix (Chaihu). This formula was approved by the CFDA as a therapeutic drug for sore eyes, lumbar debility, dizziness, hypomnesis, and body fatigue. Huang Di Nei Jing, one of the most famous ancient medical books in China, states that liver-qi is connected with the eyes; the eyes can distinguish five colors when the liver-qi is unobstructed
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