Evaluation of the hematoprotective and hepato-renal protective effects of Thymus vulgaris aqueous extract on thermally oxidized oil-induced hematotoxicity and hepato-renal toxicity

Abstract

The present study was intended to evaluate hematoprotective and hepato-renal protective effects of Thymus vulgaris against the toxicity induced by thermally oxidized oil. Rabbits were differed into four groups. Group 1, retained as normal control, groups 2–4 received T. vulgaris (2 g/kg ration, thermally oxidized oil (5% of ration), finally T. vulgaris together with thermally oxidized oil respectively. Erythrogram, showed non-significant changes at first month where, thermally oxidized oil group at third month revealed macrocytic hypochromic anemia. Also, a significant leucocytosis, monocytosis, heterophilia, and lymphopenia were perceived. There were a significant excess in malondialdehyde (MDA) level alongside, a significant subside in catalase (CAT) activity. Also the activities of liver enzymes (ALT, AST, and ALP), bilirubin, urea, creatinine, uric acid, triglycerides, cholesterol, and low density lipoprotein (LDL-c) were increased where, there were a significant reduction in serum total proteins, albumin, and high density lipoprotein (HDL-c).These alterations present in lesser level at the end of third month when T. vulgaris added together with the oxidized oil. These changes were correlated to the pathological vagaries. It could be established that using of thermally oxidized sunflower oil caused several toxicological effects on hepatic, renal, and oxidative status. Using of T. vulgaris alleviated the hematotoxicity and hepato-renal toxicity induced by addition of thermally oxidized sunflower oil.