Abstract
and r ¼0.54, P<0.001, respectively); and (2) nearly significant differences between gestational diabetes mellitus offspring and controls (a-chain: 2.35±0.21 vs 2.20±0.18%, P ¼0.049; g-chain: 2.43±0.30 vs 2.34±0.26%, P ¼0.35), whereas in mothers, A1c was slightly different (5.8±0.4 vs 5.5±0.3%, P ¼0.004). Measurement of glycation of the a-chain only might be a suggestion, as a-chain is produced throughout pregnancy. However, despite the fact that the chemical structure of the a-chain is identical in HbA and HbF, the rate of glycation of the a-chain in HbF and HbA may be different, considering that the activity of the glycation site is influenced by its three-dimensional structure rather than by the amino-acid sequences of the polypeptide. 5 Therefore, notwithstanding the views expressed by Koga et al., 1 we have shown that the determination of GHb in cord blood is feasible using EI-TOF-MS technology, and could be used as a potential glycemic control marker in neonatal diabetes mellitus.
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