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Abstract
AbstractSix triorganotin compounds—Ph3SnOH, BuPh2SnOH, (p‐CIC6H4)Ph2SnOH, (cyclo‐C5H9)Ph2SnOH, Ph3SnO2CCH2CS2NMe2 and Bu3SnOSO2Et—were tested for their mutagenic potential in somatic and germinal cells in ICR mice by using the micronucleus and spermhead abnormality assays, respectively. In somatic cells, the compunds significantly induced chromosomal disorders at half their respective estimated LD50 (i.p.) values (5.00–6.25 mg kg−1 body wt), and one compound, Ph3SnOH, even at 1/20 of its estimated LD50 value. In germinal cells, five compounds significantly induced chromosomal disorders at 1/64 of their respective estimated LD50 (i.p.) values, whereas one, (p‐CIC6H4)Ph2SnOH, caused such disorders only at 1/8 of its estimated LD50 value.
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