Abstract
Helicobacter pylori is the main cause of gastritis, peptic ulcers, gastric mucosa-associated lymphoid tissue lymphoma (MALT) and gastric cancer. H. pylori Infects more than half of the world’s population. Antibiotic treatments are not ideal because of antibiotic side effects, re-infection and increased antibiotic resistance. Vaccination against H. pylori is considered as an alternative with the suitable cost for eradication therapy. Th1 immune response plays an important role in vaccine-induced protection against H. pylori infection. An effective vaccine should be able to change the immune balance in favor of the Th1 immune response. Epitope vaccines are believed to elicit more specific and safe immune responses than other vaccines against Helicobacter pylori infection. Catalase is one of the most important immunogenic antigens of H. pylori. We found that the seven epitopes of H. pylori catalase can produce a significant Th1responses by expressing IFN-γ. A decrease in regulation levels of IL-4 was observed after stimulation with catalase epitopes. These results confirm strong response of Th1 immune to H. pylori compared to Th2 immune responses. Understanding of cellular immunity against H. pylori infection guides us to design of H. pylori appropriate vaccines better.
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