EVALUATION OF THE EXTENT OF OXIDATIVE STRESS IN BREAST CANCER PATIENTS OF INDIAN POPULATION

Abstract

Background and purpose: Oxidative stress in a cell is evident due to surplus production of oxidants because of the hysterical functioning of the system that regulates them. One such secondary product produced due to oxidative stress is malondialdehyde (MDA), a product of lipid peroxidation. To quench the effect of oxidants, antioxidant system in the cell has a signicant role. The imbalance between these two creates oxidative stress. Methods: The present study, focused on assessing the oxidative stress ratio and evaluating the levels of malondialdehyde and total antioxidant status (TAS) in breast cancer patients and healthy controls. Blood samples from breast cancer patients and age matched controls (n= 30 each. MDAand TAS estimated by pursuing Thiobarbituric Acid Reactive Substance (TBARS) Assay and Ferric Reducing Antioxidant Power (FRAP) Assay respectively. Results: The level of MDA in patients was signicantly higher (172.7 ± 81.4 nM/mL) than that of controls (77.9 ± 49.5 nM/mL) (p=0.009) whereas the level of TAS in the patients (2551 ± 1298µM/L) was signicantly lower to that of the controls (3631 ± 1123µM/L) (P=0.001). In addition, MDAand TAS levels correlated with respect to chemotherapy cycles in patients. Patients undertaking the nal stage of chemotherapy treatment had shown reduced oxidative stress than the patients in initial stage of chemotherapy, presenting a promising recovery pattern. Conclusion: The oxidative stress was evident in patients but the effectiveness of chemotherapy drugs. Foods rich in antioxidants could elevate the health and morale of the patients.