Evaluation of the estimated population prevalence of Helicobacter pylori infection and the frequency of achieving eradication after treatment based on the results of the 13C-urease breath test in individuals who applied to the federal network of the INVITRO laboratory (2019-2020, n=42,843)

Abstract

Purpose of research. Assessment of the population prevalence of Helicobacter pylori infection and the effectiveness of eradication therapy by analyzing the results of the 13 C-urease breath test ( 13 C-UBT) of surveyed patients who applied for the test to the nationwide network of medical offices of the INVITRO laboratory in 2019-2020. Materials and methods. 13 C-UBT was performed using 13 C-UREA TEST kits and IR spectrometer IRIS° - Doc, Kibion AB, Sweden. A brief questionnaire was used when applying to clarify the purpose of the request, prior medication or gastric surgery. The evaluation of the prevalence of helicobacteriosis among those who applied for screening, and the effectiveness of eradication among those who applied for therapy control, was carried out by comparison of the specified point of the examination and the results of the 13 C-UBT test, based on a selected information from the laboratory database for 2019-2020 years (n=42843). Statistical calculations of quantitative results of 13 C-UBT performed using Excel, MS programs. Results. Primary screening of H. pylori infection was the goal of the examination for 69% (n=26,127), and eradication control for 31% (n=16,716) of the surveyed persons. According to the results of 13 C-UBT, using the threshold of positive results of 4.5% and the gray zone of 3.0-4.5%, among the primary screening subjects, 39% had a positive result, 3% - doubtful, others negative. In the group of patients who applied for eradication control, 40% of the subjects completed the full course of treatment. Among those who completed the course of treatment, the infection according to the results of 13 C-UBT remained in 15%, and for the group as a whole in 17% of patients. Conclusions. Among patients who applied to a large network laboratory for initial examination, the detection rate of H. pylori infection was 39%, which probably reflects the approximate current level of prevalence of this infection in the Russian Federation. According to the results of testing for treatment control, the effectiveness of eradication therapy was 80-82%.