Evaluation of the equivalent thermal dose and power requirement for pulsed hyperthermia

Abstract

Subject to various conditions, the temperature may not reach the preset value during heat therapy. In order to ensure the medical quality of the actual treatment and improve its medical effectiveness, a comparable equivalent thermal dose should be determined. The concept of thermal isoefficient dose has been widely applied to assess the safety of that expose patients to heat. It was also reported pulsed heating causes greater cell damage than continuous heating on hyperthermia. This paper considers non-Fourier effect during pulsed hyperthermia and employs the dual phase model to simulate thermal behavior in tissue. The CEM43 model and the modified one were used to calculate thermal isoefficient dose. The amount of heating required in the therapy process was estimated for the thermal dose 305 CEM43. The present results show the model of thermal isoefficient dose significantly affects the estimation of power requirement. Shortening the heating time and increasing the power intensity can create energy saving and reduce thermal impact on the tissue surrounding the heated target while the power intensity required for pulse heating increases exponentially with the reduction of pulse width. The required power intensity reduces with the increase of τq value, and increases with the value of τT increases.