Abstract
Background: Cardiac diseases are one of the major causes of death worldwide with increasing incidence rate per year, particularly in developing countries such as Sudan owing to urbanization and changing lifestyle. Myocardial infarction is a consequence of the imbalance between the heart blood supply and the required heart cell; this disorder leads to necrosis of myocardium and may cause death. It could be diagnosed by at least two of the following criteria: chest pain, electrocardiography (ECG) elevation, and levels on cardiac biomarkers. This study aimed to evaluate the efficiency of N-terminal pro-B-type natriuretic peptide (NTproBNP) for the diagnosis of acute myocardial infarction (AMI).
 Methods: This analytical case–control hospital-based study was conducted on a total of 70 individuals, of which 40 participants were suspected of or diagnosed with AMI, while 30 healthy subjects were included as a control group. Three ml of venous blood were collected in lithium heparin containers. Troponin I (TnI) as a cardiac biomarker was measured by TOSOH AIA-360, while the NTproBNP level was detected using I-Chroma II. Personal and clinical data were collected directly from each participant using a predesigned questionnaire.
 Results: A significant increase in the TnI level (mean: 13.13 ± 18.9 ng/ml) and NTproBNP (mean: 5756.5 ± 8378.2 pg/mL) in AMI patients were detected when compared with control mean (0.02 ± 0.00 ng/ml and 57.8 ± 42.32 pg/mL, respectively).
 Conclusions: NTproBNP gave a high sensitivity (87.5%), specificity (100%), positive predictive value (100%), and negative predictive value (85.7%) in the diagnosis of AMI when compared with another cardiac biomarker such as TnI.
 Keywords: acute myocardial infarction, NTproBNP, troponin I, Medani Heart Center, Sudan
Highlights
A cardiac disease refers to any disorder that affects the heart function by either minimizing or eliminating the heart output [1]
The frequency of myocardial infarction (MI) has increased over the last few decades throughout several states of Sudan, which may be due to the increase in the prevalence of risk factors such as underlying diseases and habits [5]
This study enrolled 40 patients with acute myocardial infarction (AMI), among whom 62.5% were male, 45% diabetic, 40% hypertensive, 25% smokers, 25% obese,97.5% has no history of cardiac diseases
Summary
A cardiac disease refers to any disorder that affects the heart function by either minimizing or eliminating the heart output [1]. An acute myocardial infarction (AMI) is a consequence of the imbalance between the heart blood supply and the required heart cell This disorder leads to necrosis of the myocardium and may even cause death [1].MI is the most common cause of death worldwide [3, 4]. Myocardial infarction is a consequence of the imbalance between the heart blood supply and the required heart cell; this disorder leads to necrosis of myocardium and may cause death. It could be diagnosed by at least two of the following criteria: chest pain, electrocardiography (ECG) elevation, and levels on cardiac biomarkers. Conclusions: NTproBNP gave a high sensitivity (87.5%), specificity (100%), positive predictive value (100%), and negative predictive value (85.7%) in the diagnosis of AMI when compared with another cardiac biomarker such as TnI
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