Evaluation of the efficacy of levocarnitine in supporting therapy in multiple myeloma

Abstract

The accompanying therapy prescribed during the use of toxic drugs helps patients to complete the treatment to the end, and the doctor adheres to the treatment of the chosen line The aim of the study was to study the effect of levocarnitine on blood biochemical parameters and on chemotherapy tolerance. Materials and methods. The study was conducted in the stem cell treatment department at Republican Specialized Scientific Practical Medical Center of Hematology . Chemotherapy toxicity was assessed according to WHO and NCIC standards. Results. In a comparative study, 30 patients receiving chemotherapy for myeloma with varying degrees of toxicity when fortecarnite (100 mg / kg / day) was added to standard therapy for 2 months or more showed a significant positive change in cytochemical parameters (Alanin transferase (ALT), aspartat transferase (AST)), which allowed the authors recommend metabolic correction to all patients receiving chemotherapy, especially with 2nd and 3rd degree of toxicity.