Abstract
Objective: The aim of this study was to compare the efficacy of leukocyte-platelet-rich fibrin (L-PRF) and platelet-rich fibrin matrix (PRFM) on bone healing.Methods: Eight rabbits were included in this controlled, prospective, blinded study. Defects with a diameter of 3 mm and 2 mm depth were created in the bone of both tibias, filled with L-PRF (group II), PRFM (group III) or left empty (group I). The bone mineral density (BMD) was measured by dual energy absorptiometry (DXA) and histological examination was performed on the 10th and 21st days.Results: According to Emery’s histopathological healing criteria, control group (group I) revealed score 0 and score 3 at 10 and 21 days respectively. Group II showed score 2 and score 5 at 10 and 21 days respectively. On the other side group III treated by PRFM showed score 3 and score 7 at 10 and 21 days respectively. Conclusion: Both L-PRF and PRFM showed increased bone formation in surgically created bone defects in rabbits, however, the effect of PRFM was more pronounced. The use of PRFM and L-PRF may contribute to the success of bone regeneration.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
