Evaluation of the Efficacy of Leukocyte-Platelet Rich Fibrin versus Platelet Rich Fibrin Matrix on Bone Healing

Abstract

Objective: The aim of this study was to compare the efficacy of leukocyte-platelet-rich fibrin (L-PRF) and platelet-rich fibrin matrix (PRFM) on bone healing.Methods: Eight rabbits were included in this controlled, prospective, blinded study. Defects with a diameter of 3 mm and 2 mm depth were created in the bone of both tibias, filled with L-PRF (group II), PRFM (group III) or left empty (group I). The bone mineral density (BMD) was measured by dual energy absorptiometry (DXA) and histological examination was performed on the 10th and 21st days.Results: According to Emery’s histopathological healing criteria, control group (group I) revealed score 0 and score 3 at 10 and 21 days respectively. Group II showed score 2 and score 5 at 10 and 21 days respectively. On the other side group III treated by PRFM showed score 3 and score 7 at 10 and 21 days respectively. Conclusion: Both L-PRF and PRFM showed increased bone formation in surgically created bone defects in rabbits, however, the effect of PRFM was more pronounced. The use of PRFM and L-PRF may contribute to the success of bone regeneration.