Evaluation of the efficacy of dipeptidyl peptidase-4 enzyme and selenium element in people with kidney failure in Kirkuk governorate

Abstract

The samples were collected between the period 12/2020–3/2021, and the number of patient samples was 75 blood samples, which were divided into 30 blood samples from patients before and after the hemodialysis process, and 15 blood samples from patients taking treatment they did not undergo hemodialysis, their ages ranged between 20 and 55 years. Twenty-five 25 blood samples were collected from apparently healthy people, ranging in age from 20 to 55 years, and specialized doctors diagnosed the disease cases. The results showed a significant increase in the activity of the enzyme Dipeptidyl Peptidase-4 (DPP-4) in the total patients 59.161 ± 4.070 UI/L with a probability level of P ≤ 0.01 compared with the healthy controls 35.380 ± 10.278UI/L, where the rate of the activity of enzyme Dipeptidyl Peptidase-4 in the serum of patients with renal failure before hemodialysis 86.053 ± 12.008 UI/L as well as increased in the blood of patients with renal failure who are receiving treatment was 57,855 ± 9.415 UI/L. While the concentration of enzyme decreased in the serum of patients with renal failure after hemodialysis 51.579 ± 8.788 UI/L compared to the group of patients before hemodialysis and during treatment, and fall at the probability level of P ≤ 0.01 in the class and concentration of selenium at the total level of patients as well as before and after the hemodialysis process. In contrast, its level increased among the patients taking the treatment and at the level of the probability P ≤ 0.01 compared to its level in all patients and before and after the dialysis process bloody. The effect of age on the status of the enzyme Dipeptidyl Peptidase-4 and selenium was also studied in according groups of patients, it found a significant impact of age on the level of the enzyme and the selenium element, as substantial differences were found that indicated the high level of the enzyme and the selenium element in elderly patients aged 36–55 years, while it decreased slightly in young patients whose ages ranged from 20 to 35 years old.