Abstract
Background. This clinical trial evaluated the effect of Simvastatin on space re-opening after orthodontic space closure and its effect on the gingival index (GI) and clinical attachment loss (CAL).Methods. 16 females, 25-40 years old, with spaces between anterior mandibular teeth due to chronic periodontitis were participated in this study. The patients were randomly divided into control and experimental groups. In the experimental group, 1.2% Simvastatin gel and in the control group, 0.9% sodium chloride as a placebo was injected into the pocket depth of the six anterior teeth. The amount of space reopening, GI and CAL were measured.Results. No serious complications were observed during interventions and follow-up periods. Space re-opening was significantly reduced in patients receiving Simvastatin (P < 0.001). Moreover, GI reduction was significantly greater in Sim-vastatin group compared to the control group (P < 0.001). However, CAL did not demonstrate a significant difference between the groups.Conclusion. Simvastatin may decrease space re-opening after orthodontic space closure in human anterior teeth.
Highlights
There is a great tendency to relapse after orthodontic tooth movement.[1]
This clinical trial evaluated the effect of Simvastatin on space re-opening after orthodontic space closure and its effect on the gingival index (GI) and clinical attachment loss (CAL)
GI and CAL showed no significant differences before the beginning of orthodontic treatment between the two groups (P = 0.51 and P = 0.63, respectively)
Summary
There is a great tendency to relapse after orthodontic tooth movement.[1]. Contemporary retaining strategies in orthodontics basically include removable and fixed retainers. On the other hand, fixed retainers, which are usually used for long-term retention after orthodontic treatment, make oral hygiene more difficult.[2]. Considering these problems, a few recent studies have suggested that pharmacologic therapy might. SMV may provide a new direction in controlling relapse of orthodontic treated cases. This clinical trial evaluated the effect of Simvastatin on space re-opening after orthodontic space closure and its effect on the gingival index (GI) and clinical attachment loss (CAL). Simvastatin may decrease space re-opening after orthodontic space closure in human anterior teeth
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