Abstract
The in vivo effects of inorganic mercury (Hg 2+) on striatal dopamine (DA) release were studied in freely moving and conscious rats using brain microdialysis techniques. Intrastriatal administration of HgCl 2 (1 mM) produced an increase in extracellular DA levels of 1717 ± 375% with respect to basal levels. This effect was attenuated in a Ca 2+-free medium (361 ± 66%), after pre-treatment with reserpine (231 ± 66%), and was prevented in the presence of tetrodotoxin (TTX). Thus, the HgCl 2 treatment increases striatal DA according to an external calcium and vesicular dependent mechanism, being affected by the blockade of voltage sensitive sodium channels. Moreover, HgCl 2 decreased KCl-evoked DA release. Conversely, the coinfusion of HgCl 2 with nomifensine produced increases in DA extracellular levels different to that produced by nomifensine alone, suggesting that these effects probably involve an independent DA transporter (DAT) mechanism.
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