Evaluation of the effect of using different doses of levothyroxine on some biochemical parameters in hypothyriod patients

Abstract

The current study included the collection of ninety serum samples to evaluate the effect of using different doses of levothyroxine on some biochemical parameters in patients with thyroid disorders. Samples were collected for the period between 15/9/21 to 10/1/2022. Sixty samples were taken from patients with hypothyroidism(G1) who subdivided into two subgroups; 26 of them took the levothyroxine dose of 200 µg/day (G2), and 34 of them took the levothyroxine dose of 100 µg/day (G3), and 30 samples were taken as a control group, their ages ranged between (46-60) years. The level of hepcidin hormone and the activity of the alkaline phosphatase-ALP, Alanine amino transferase-ALT, and Aspartate amino transferase-AST enzymes were evaluated in the serum of hypothyroid patients and healthy subjects as a control group. The results showed that the level of hepcidin hormone significantly (P≤0.05) elevated in serum of patients in group (G3) than the control group and the rest of the other groups. The results showed a significant increase(P≤0.05) in the activity of aspartate aminotransferase enzyme, alanine transferase enzyme and alkaline phosphatase enzyme activities in the serum of patients with hypothyroidism compared to the control group.