Abstract
Biota orientalis L. leaf extract (BOLE) is used medically to improve strength and arrest hemorrhage. In China, BOLE has been used in traditional medicine for its antibacterial properties and for hair restoration. In this study, we investigated the mechanism of hair restoration by BOLE from the point of view of the sebum suppressant effect and hair loss prevention. BOLE at 25 or 50 μg/mL final concentrations, a hair growth plant ethanol extract (HGPEE), and a hair growth plant water extract (HGPWE) (the latter two each containing BOLE and other plant compounds), were used to study: (1) the sebum suppressant effect in sebocytes from normal golden hamster ear pinna origin; (2) the effect on the growth of human fetal epidermal keratinocytes; and (3) the effect on gene expression related to hair growth stimulation, with (2) and (3) studied in human fetal epidermal keratinocytes and hair papilla cells. BOLE had a sebum depletion effect in cultured sebocytes; moreover, the amounts of mRNA of the hair growth factors, KGF, VEGF, and G3PDH analyzed by real-time polymerase chain reaction in human hair papilla cells were increased by HGPEE. The amount of mRNA of Wnt10b in cultured epidermal keratinocytes was increased by the addition of BOLE, and the growth of the cultured epidermal keratinocytes was promoted by HGPEE in a two-layer culture system of hair papilla cells and epidermal keratinocytes. HGPEE had a hair growth promotion/hair restoration effect and a sebum suppression effect. Hair restorers containing HGPEE may be useful for stimulating hair growth and suppressing excess scalp sebum in males and females.
Highlights
Sometimes the skin excretes oil from pores in excessive amounts
We investigated the mechanism of hair restoration by Biota orientalis L. leaf extract (BOLE) on the basis of the sebum suppressant effect
As BOLE and hair growth plant ethanol extract (HGPEE) decreased the amount of sebum per cell relative to that by the control, it is is thought that they could be useful for preventing hair loss caused by excessive scalp sebum secretion thought that they could be useful for preventing hair loss caused by excessive scalp sebum secretion in in males and females
Summary
Sometimes the skin excretes oil from pores in excessive amounts. The scalp has a higher quantity of sebum than the face, with excessive oil excreted from pores. Excessive lipid content on the top of the head (more than on the temporal and occipital regions) contributes to hair loss. The scalp’s sebum, containing triglycerides, fatty acids, squalene and wax esters, are produced by the sebaceous gland [1]. Other lipids on the scalp’s surface, such as cholesterol esters and cholesterol, mainly originate from epidermal cells [1]. There are more wax esters and fatty acids in the scalp than those on facial skin
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