Evaluation of the Effect of Obesity and Race on Incidence of Endometrial Cancer 2000-2016 [26H

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INTRODUCTION: To examine and describe the trends and measure the association between obesity and endometrial cancer among American adults between 2000 and 2016 stratified by both race and age. METHODS: Data from the National Cancer Institute’s Surveillance, Epidemiology and End Results database to evaluate trends in age-adjusted uterine cancer incidence rates stratified by race. In this evaluation average annual percent change (AAPC) was used to quantify changes in incidence rates from 2000-2016 and calculated using joinpoint regression. Rates of obesity in female patients were calculated using the National Health and Nutrition Examination Survey from 2001-2016. IBM SPSS tool was used to calculate rate of obesity and conduct a multiple linear regression analysis was performed to determine the relationship between obesity and the incidence of endometrial cancer. RESULTS: During 2000-2016, uterine cancer rates overall increased at 0.7% per year average. There is a significant difference in the average annual percent change (AAPC) when stratified by race especially in pre-menopausal patients with overall rates increased at 3.0% per year, with rates in whites 2.2% per year, blacks 2.4% per year, and Hispanic’s 4.3% per year. The AAPC in the prevalence of obesity in the pre-menopausal patients revealed AAPC for white patients 0.5%, black 0.6%, and Hispanics of 0.9%. Linear regression analysis indicates that obesity alone doesn’t account for the increase in endometrial cancer in pre-menopausal Hispanic patients. CONCLUSION: During 2000-2016 there has been an increase in uterine cancer in Hispanic populations that is not solely explained by increasing rates of obesity particularly in the pre-menopausal population.