Evaluation of the Effect of Ferula Rigidula Extract on Sperm Parameters, Antioxidant Parameters and Testicular Structure in Male Rats in Experimental Diabetic Condition

Abstract

The study was conducted to investigate how Ferula rigidula extract affected sperm profile, antioxidant parameters, and stereological profile in experimental diabetic rats. Performed on forty-nine male rats. The rats were randomly assigned to control group, diabetic group, diabetic + Ferula rigidula group 1, diabetic + Ferula rigidula group 2, diabetic + glibenclamide group, Ferula rigidula group 1, and Ferula rigidula group 2. While sperm count, motility, antioxidant parameters, testosterone hormone, germinal epithelial volume, and germinal epithelial height decreased in the diabetic group, abnormal sperm count, malondialdehyde level, and lumen volume increased. When Ferula rigidula (extract) was given to diabetic rats, it brought the stereological findings to the same level as the control group. In addition, it was determined that there were improvements in biochemical parameters, approaching the values of the control group. Specifically, when Ferula rigidula extract was administered alone, testosterone levels and stereological findings improved in group 1. In addition, it was determined that there were significant improvements in sperm parameters. However, it was determined that the positive effect of Ferula rigidula extract was very significant at low doses (250 mg/kg) and decreased at high doses (500 mg/kg). As a result, Ferula rigidula extract has an antioxidant role and can be used to alleviate the problems caused by diabetes in the male reproductive system.