Abstract
Inflammation is a defense response against human death by physical, chemical or biological agents, which triggers, among other factors, pain. Despite being a warning and protection signal, it decreases the life quality.In view of this, research into new antinociceptive therapeutic options is necessary. As it was verified that the keratinocytes of the basal stratum of the epidermis release endogenous opioid, being an important antinociceptive mechanism, the best understanding of the relationship between peripheral nervous system, skin (keratinocytes) and analgesia is important.Thus, the present study aims to evaluate the analgesic potential of culture supernatant of human keratinocytes in the experimental model of inflammatory hyperalgesia. The purpose of it is to establish the anti-hyperalgesic mechanism and time of action, which may bring a new way of local treatment of inflammatory hyperalgesia.
Highlights
Inflammation is a defense response against human death by physical, chemical or biological agents, which triggers, among other factors, pain, as a warning and protection signal
As it was verified that the keratinocytes of the basal stratum of the epidermis are responsible for the release of such opioid, this direct relationship between the peripheral nervous system and keratinocytes is evidenced as a promising research field for different forms of analgesia, mainly because of its local action[3]
After 0.5, 1, 2, 4 and 6 hours of supernatant administration, the mechanical hyperalgesia was assessed by the von Frey test
Summary
Inflammation is a defense response against human death by physical, chemical or biological agents, which triggers, among other factors, pain, as a warning and protection signal. It is known that endogenous mechanisms that counteract pain and inflammation, such as the release of endogenous opioids by immune cells, are produced[2]. As it was verified that the keratinocytes of the basal stratum of the epidermis are responsible for the release of such opioid, this direct relationship between the peripheral nervous system and keratinocytes is evidenced as a promising research field for different forms of analgesia, mainly because of its local action[3]. The present study aims to evaluate the analgesic potential of culture supernatant of human keratinocytes in the experimental model of inflammatory hyperalgesia.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Revista dos Trabalhos de Iniciação Científica da UNICAMP
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
