Abstract
Antibiotic-loaded bone cement (ALBC) is commonly used in joint replacement therapy for prevention and treatment of bone infection and mechanical properties of the cement is still an important issue. The effects of ciprofloxacin and vancomycin was investigated on mechanical characterization of PMMA bone cement. Different properties of cement containing (0, 2.5, 5 and 10% W/W) antibiotics, including compressive and bending properties, microstructural, porosity and density were evaluated. Both antibiotics significantly reduced the density values and mechanical properties (compressive and flexural strength and modulus) in all groups in comparison to control over first two weeks (p < 0.05). This reduction was due to increased porosity upon antibiotic addition (3.05 and 3.67% for ciprofloxacin and vancomycin, respectively) in comparison to control (2.08%) (p < 0.001) and exposure to aqueous medium. Vancomycin as antibiotic with higher molecular weight (MW = 1485) had significant effect on compressive strength reduction of the cement at high amount compared to ciprofloxacin (MW = 367) (P < 0.01), there was no difference between two antibiotics at lower concentrations (P > 0.05). The effect of antibiotic loading is both molecular weight and drug content dependent. The time is also an important parameter and the second week is the probably optimum time to study mechanical behavior of ALBC.
Highlights
To the best of our knowledge there is no study comparing the effects of ciprofloxacin and vancomycin addition in bone cement
Impregnation of 2.5, 5 and 10% of this drug led to decreases equal to 7, 15 and 35.5%, respectively, on day 14. These results showed a linear correlation between the reduction of compressive strength and the concentration of vancomycin up to 10% (Fig. 1b, r2 = 0.935, P < 0.001)
The cement containing 2.5% of both antibiotics showed acceptable compressive strength according to ISO5833 standard level (
Summary
The purpose of this study was to investigate mechanical properties of cement impregnated with these antibiotics by means of static mechanical tests over 28 days
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