Evaluation of the ef ectiveness of alimentary correction of pathological changes in hepatic tissue under the inf uence of industrial copper-containing dust in the experiment

Abstract

The results of comparative studies of the long-term ef ect (dynamics) of polymetallic dust containing 0.6% copper in the shops of Balkhash mining and metallurgical combine on the liver of rats are presented. These data on the action of dust with a predominant copper content of 0.6% give reason to assert that in the liver for 30 days there were changes in the structure, which were ref ected by metabolic rearrangements and are characterized as a failure of adaptation. The phenomena of hepatitis also took place on day 90, but these changes led to a decrease in the rate of metabolic processes. Microscopic examination showed that long-term exposure to polymetallic dust with a copper concentration of 0.6% in the body leads to signif cant changes in the liver reactive character, followed by transformation into hepatitis portal type. There is an accumulation of copper in the cytoplasm of hepatocytes; on day 90, the number of dust particles in rat hepatocytes increases by 2.25 times compared to 30 days of the experiment. T is can be explained by the inhibition of the phagocytic function of liver macrophages and ways to eliminate dust from the body. The lat er, in turn, leads to functional and metabolic damage to the structural component of the organ. It should be noted that an important role in the neutralization and removal of copper from the cell belongs to lysosomes. T ere is an assumption that copper damages lysosomal membranes and stimulates the release of enzymes from lysosomes due to a decrease in the number of mitochondria in the cell or inhibition of their enzymes. Thus, the ef ects of polymetallic dust with a copper concentration of 0.6% in the body in the early stages leads to changes in the liver, in the form of reactive hepatitis with subsequent transformation into portal-type hepatitis. The use of alimentary corrections slows down the development of post-necrotic f brosis in the liver, and there was a signif cant decrease in the volume fraction of f brotic liver tissue.