Abstract
S. nothohybrida Valdespino and S. lepidophylla (Hook & Grev) Spring (Selaginellaceae) (doradillas) are used in the Mexican traditional system of medicine to treat renal pain, gall and renal stones, cystitis and as diuretics, among others. The aim of this study was to evaluate the diuretic potential of the decoctions of these two plants, from which, biflavonoids as amentoflavone (1), robustaflavone (2), (2S)-2,3-dihydrorobustaflavone (3) and the carbohydrate trehalose (4) have been isolated. Effects on the excretion of electrolytes and urine volume at 4h, treating mice with compounds 1, 2, 4 and decoctions were evaluated. The results showed diuresis in all cases; natriuretic effect was also observed in all cases except for biflavonoid robustaflavone (2) which behaved as the reference compound furosemide. In mice pretreated with acetyl salicylic acid, sodium naproxen, indomethacin and Celecoxib as COX's inhibitors, compounds 1, 2 and 4 observed inhibition of diuresis. S. nothohybrida decoction behaved similarly in the assay with COX-2 inhibitor Celobiox. Results show a possible mechanism through renal prostaglandins inhibition.
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