Evaluation of the diagnostic performance of estimated fecal calprotectin and serum intelectin-1 and C-reactive protein solo or in combination for differentiation between patients with query ulcerative colitis, Crohn’s disease and irritable bowel syndrome

Abstract

Background: Gut-brain contact has been linked recently to functional gastrointestinal problems. This interaction begins with immune cells invading the mucosa, which then causes intestinal cells to release nociceptive mediators either directly or indirectly. These mediators can cause visceral hypersensitivity by activating sensitized neurons. Reduced serum levels of intelectin-1 may distinguish among studied cases with UC & healthy controls as well as among IBS studied cases & studied cases with UC. This is as UC studied case samples had significantly lower levels of ITLN1 than do control & IBS studied case samples, & IBS studied case samples & healthy controls did not differ significantly. Aim: in this review; Our objective was to assess the diagnostic efficacy of serum intelectin-1, C-reactive protein, & estimated faecal calprotectin alone or in combination for distinguishing individuals with ulcerative colitis from those with irritable bowel syndrome, Summary: High FCP & low serum ITLN1 together can be able to distinguish UC from IBS, predict colonoscopic & microscopic results of UC, & avoid the need for colonoscopy & biopsy, particularly in IBS studied cases. Raised FCP & lowered serum ITLN1 may distinguish UC from IBS by precisely predicting the microscopic & colonoscopic diagnostic results of UC.