Abstract
Evaluation of the diabetes contribution to the occurrence of treatment related toxicities in multimodal treated locally advanced head and neck cancers
Highlights
Head and neck squamous cell carcinoma accounts for approximately 6.5% of cancer cases with anoverall survival at 5 years of approximately 55%
All patients received curative intent radiotherapy in a total dose of 70Gy in 35 fractions using intensified modulated radiotherapy (IMRT) or volumetric arc therapy (VMAT) techniques.The RECIST/ RECIST 1.1 criteria were used in all cases to evaluate the imaging response to induction chemotherapy
Radio-mucositis and dysphagia occurred most frequently starting from the 2nd week of treatment, requiring symptomatic treatment in all cases
Summary
Head and neck squamous cell carcinoma accounts for approximately 6.5% of cancer cases with anoverall survival at 5 years of approximately 55%. Cancer has in common with diabetes increased insulin and IGF-1 secretion, metabolic alterations and changes in the immune system with the release of pro-inflammatory cytokines. Cancer has been seen as an abnormality in proliferation, but modern vision includes neoplasms among metabolic diseases. Malignant cells reprogram metabolism in order to provide their nutritional substrate adapted to their needs. Tumor cell causes increased consumption of glucose and glutamine and increased glycolysis[2]. Obesity, pancreatitis, chronic stress can cause hyperglycemia. Cancer is recognized as a chronic condition associated with hyperglycemia considered associated with being associated with tumorigenesis or tumor progression. The most common associations were between diabetes and hepatic and pancreatic cancers, with a higher incidence than the general population[4]
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