Abstract
The skin irritation and sensitization potential of the new transdermal patch of the Thiocolchicoside formulated with Dura 87-6908 was evaluated on the rabbits and guinea pig as per the standard guidelines of OECD. Skin irritation test was performed on the rabbits by applying the placebo patch for 72 hours and dermal reactions like edema, erythema were noted. No clinical signs or dermal reactions were observed in the rabbits. Sensitization potential was measure on the guinea pig and animal was challenged to transdermal therapeutic system of the Thiocolchicoside, negative control group while group exposed to CDNB produced the sensitization reactions. These findings proved that Thiocolchicoside does not produce any dermal toxicity, irritation and sensitization and hence it is safe for dermal use.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
