Abstract
Background Evidenced by their traditional use and through scientific studies, natural products have been important participants in drug discovery, providing novel structures that can be used as potential drugs. Among the plants investigated to date, those of the Baccharis genus are important sources of natural medicinal products. Comprising more than 500 species distributed throughout the North and South American continents, this genus is commonly used in folk medicine as antipyretic agents, antirheumatic and to control hyperglycemia. B. gaudichaudiana, popularly known as “carquejeira-doce” is found in grasslands, Brazilian savannas, and less pronounced in tropical humid lowland. Many secondary metabolites have been characterized and isolated, such as flavonoids, diterpenes, tannins, saponins and essential oils.
Highlights
Evidenced by their traditional use and through scientific studies, natural products have been important participants in drug discovery, providing novel structures that can be used as potential drugs
In order to evaluate the cytotoxic and mutagenic potentials of the ethanolic extract of B. gaudichadiana, the Somatic Mutation and Recombination Test (SMART) in wing somatic cells of Drosophila melanogaster, was performed employing two genetic markers located on the left arm of chromosome 3: multiple wing hairs a homozygous-viable recessive mutation that produces multiple trichomes per cell instead of one trichome; and flare3 - a recessive mutation that produces flare-shaped wing hairs
For the ST cross, virgin flare-3 females were mated with mwh males
Summary
Evidenced by their traditional use and through scientific studies, natural products have been important participants in drug discovery, providing novel structures that can be used as potential drugs. Methods In order to evaluate the cytotoxic and mutagenic potentials of the ethanolic extract of B. gaudichadiana, the Somatic Mutation and Recombination Test (SMART) in wing somatic cells of Drosophila melanogaster, was performed employing two genetic markers located on the left arm of chromosome 3: multiple wing hairs (mwh, 3-0.3) a homozygous-viable recessive mutation that produces multiple trichomes per cell instead of one trichome; and flare[3] (flr3, 3-38.8) - a recessive mutation that produces flare-shaped wing hairs. Three D. melanogaster strains were used: 1) multiple wing hairs: y; mwh j; 2) flare-3: flr3/ In (3LR)TM3, ri ppsep l(3)89Aa bx34ee BdS; and 3) ORR; flare-3: ORR; flr3/In(3LR)TM3, ri ppsep l(3)89Aa bx34ee
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