Abstract
Abamectin, a widely used pesticide with insecticidal, anthelmintic, and acaricidal properties, has raised safety concerns due to its toxic effects on certain non-target organisms. The toxicity of abamectin, the active ingredient in the commercial pesticide formulation Alopec? EC, was evaluated using cytogenetic and comet assays on Allium cepa root tips. Mitotic index (MI) and phase index (PI) values were used for cytotoxicity assessment. Chromosomal aberration (CA) frequencies in the dividing cells and comet data were used for genotoxicity assessment. The root growth test showed a significant concentration-based decline in root growth after abamectin exposure, with a median effective concentration (EC50) of 2.50 mg/L. Following 96-hour exposure to three concentrations of abamectin (1.25, 2.50, and 5.00 mg/L), cytogenetic and comet analyses indicated a significant concentration- and time-dependent decrease in the MI, alongside an increase in DNA damage. Additionally, there was a significant concentration-dependent rise in the total frequency of CAs. These findings show that abamectin is a pesticide with lethal effects on A. cepa root tip meristematic cells, even at lower concentrations, over prolonged exposure times, with CA-forming and DNA-damaging effects, and that it is highly cytotoxic and genotoxic.
Published Version
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