Evaluation of the corneal pachymetry and biomechanical parameters changes in patients treated by prostaglandins topical medication

Abstract

AbstractPurpose To assess the possible corneal changes after topical prostoglandins treatment.Methods Prospective study including 15 patients newly diagnosed with OHT or POAG needed to be treated. The patients had complete basic ophthalmological examination before treatment (D0). IOP was measured with Goldmann aplanation tonometer, Pascal contour tonometry and ocular response analysis (ORA). The corneal biomechanical parameters, CRF and CH were measured as well with ORA. Axiale length and the anterior chamber depth were measured using IOL master. The pachymetry was performed using an ultrasound pachymeter. These examinations were repeated on D42 and D90. Anova test for repeated measurements was used for statistical analysisResults The mean CCT was 552.6 ± 30 µ on D0, 548.8 ± 32 µ on D42 and 542.6 ± 31µ on D90. There was a significant difference between the CCT measurements on D0 and D90 (p= 0.006). The mean CRF on D0, D42 and D90 was: 11.8 ± 2.3 mmHg, 10.6 ± 1.7 mmHg and 10.7 ± 1.8 mmHg respectively. There were no significant differences between these values. The mean CH on D0, D42 and D90 was: 8.8 ± 2.1 mmHg, 9.6 ± 1.6 mmHg and 10 ± 2 mmHg respectively. There were no significant differences between these values.Conclusion In this study we found a significant decrease of CCT after topical prostaglandins treatment. We didn’t find any significant change in corneal biomechanic parameters after treatment.