Abstract
10630 Background: Chemokine SDF-1α and its receptor CXCR4 have been shown to impact cancer progression. Accumulating evidence suggests that CXCR4 and SDF-1α expression is useful for evaluating the risk of gastric cancer progression. CXCR4 expression is associated with lymph node metastasis and development of peritoneal carcinomatosis in patients with gastric cancer, and SDF-1α expression in the primary cancer is reported to be an independent prognostic factor in these patients. Thus, combined analysis of SDF-1α and CXCR4 would have strong prognostic potential as a molecular marker for gastric cancer. Here we investigated for the first time the effects of combined CXCR4 and SDF-1α expression on the prognosis of patients with gastric cancer. Methods: We studied SDF-1α and CXCR4 protein expression in 221 specimens of primary gastric cancer using immunohistochemistry, and analyzed the clinicopathological features and clinical outcomes. Results: Patients were categorized into three groups according to CXCR4 and SDF-1α expression: high CXCR4/high SDF-1α, low CXCR4/low SDF-1α, and high CXCR4/low SDF-1α–low CXCR4/high SDF-1α. No significant differences existed in age, gender, histology, tumor location, lymphovascular invasion, or proportion of tumor size < 5 cm among the three groups. However, high CXCR4/high SDF-1α expression in tumor cells was significantly associated with invasion depth of the tumor (T status; p = 0.001), lymph node involvement (N status; p = 0.029), and higher tumor stage (p = 0.001) compared to tumors with low CXCR4/low SDF-1α expression or high CXCR4/low SDF-1α–low CXCR4/high SDF-1α expression. Furthermore, patients with high CXCR4/high SDF-1α expression had the worst prognosis (5-year survival rate 26.7%; median, 2.2 years; range, 0.8 - 3.6 years), whereas patients who had low CXCR4/low SDF-1α expression showed the most favorable prognosis (5-year survival rate, 57%; median, not reached; log-rank test, p = 0.01). Conclusions: CXCR4 and SDF-1α are useful prognostic factors in gastric cancer, and the combination of high CXCR4 protein expression with high SDF-1α expression suggests a dismal prognosis. No significant financial relationships to disclose.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
