Abstract
s / Osteoarthritis and Cartilage 23 (2015) A82eA416 A404 4 courses, and 760 (1.5%) received 5 courses or more. The time from diagnosis to when 50% of the subset received TKR was significantly longer (p1 year, an average of 9 months longer than those with no IA HA. Patients who received 5 courses had a delay in TKR by 3.6 years. Conclusions: Among 182,022 patients with knee OA, those who received IA HA had a significantly longer time before TKR. More courses of IA HA injections were associatedwith a longer time toTKR. This study suggests a significant clinical benefit from use of IA HA for OA as delay in time to TKR can have important clinical and economic implications. Median Time from knee OA diagnosis to TKR by number of courses of IA HA
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