Abstract
Chronic intermittent hypoxia (CIH) induces hypertension in juvenile and adult male rats due to an increase in sympathetic activity. There is experimental evidence that changes in respiratory network are driving the sympathetic overactivity in this model. Female rats are more resistant to the development of hypertension in several experimental models. In this study, we evaluated the cardiovascular changes in juvenile and adult female rats in response to CIH. Juvenile female rats were exposed to CIH for a 10 days protocol and adult female rats to a 35 days protocol and at the end of the protocols direct measurements of arterial pressure were performed in control and CIH rats. Juvenile female rats exposed to CIH (n=30) presented significant increase in arterial pressure compared to their respective control [n=34 (94±1 vs 86±1 mmHg, p<0.05)], as well adult female rats exposed to CIH (n=27) when compared to their respective control [n=26 (111±1 vs 104±1 mmHg, p<0.05)]. We concluded that juvenile and adult female rats submitted to CIH develop high arterial pressure similarly to male rats after CIH, suggesting that sexual characteristics and hormones are not playing a protective role in this experimental model of hypertension.Grant Funding Source: Supported by CAPES, CNPQ and FAPESP
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