Abstract
Action Potential in Rabbit Purkinje Fibres (at 1 Hz) Cardiac toxicity of Tricyclic Antidepressant drugs (TCAs) is in part related to the blockade of cardiac ionic channels such as sodium, calcium or potassium channels (1), leading to lengthening both depolarisation and repolarisation phases of the cardiac action potential. These electrophysiological effects result in changes in the ECG, such as prolongation of the PR, QRS or QT intervals, and contribute to life threatening ventricular arrhythmia (2)(3)(4)(5).
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