Evaluation of the C60 biodistribution in mice in a micellar ExtraOx form and in an oil solution

Konstantin N Semenov,Andrey V Petrov,Vladimir V Sharoyko,Sergei V Ageev,Daria A Ivanova,Igor V Murin,Anatolii A Meshcheriakov,Ekaterina M Volochaeva,Nikita E Podolsky,Ekaterina M Fedorova,Egor E Zakharov

doi:10.1038/s41598-021-87014-3

Abstract

The article is devoted to the study of the pharmacokinetics of fullerene C60 in oil and micellar forms, analysis of its content in blood, liver, lungs, kidneys, heart, brain, adrenal glands, thymus, testicles, and spleen. The highest accumulation of C60 was found in the liver and adrenal glands. As a result of the studies carried out, it was shown that the bioavailability of C60 in the micellar form is higher than that in an oil solution.

Highlights

Attention to fullerenes as a basis for the design of biologically active substances is determined by their following properties: size, lipophilicity, structure, chemical and photophysical properties
In ref.[7], systems for the transfer of proteins enriched with L-arginine, which are able to penetrate through bilayer membranes, were developed using the fullerene derivative C60(COOH)[2]
Of particular interest is the presence of an internal volume in fullerene molecules, their ability to form endohedral metallofullerenes (EMF)[10,11,12,13,14]

Summary

Introduction

Attention to fullerenes as a basis for the design of biologically active substances is determined by their following properties: size, lipophilicity, structure (presence of internal volume), chemical and photophysical properties. The oil and micellar forms of fullerene C60 were used. The micellar form of fullerene in oil was obtained using the original ExtraOx technology developed by “AQUANOVA RUS” J SC53.

Results

Conclusion