Abstract
Objective: Plants have significant potential effects in treating the wound. The vast majority of plants are used by the public in the treatment of wounds. The aim of this study was to investigate the antioxidant and in vitro wound healing activities of Centaurea virgata (C. Virgata).
 Methods: The antioxidant activities of extracts were examined by 2,2-diphenyl-1-picryl-hydrazyl (DPPH) and ABTS methods. The amount of total phenolic was determined using the Folin-Ciocalteu reagent (FCR) method. In addition, the antiproliferative activity of different extracts on fibroblast cells were performed by MTT method and in vitro wound healing activity of ethanol extract of C. Virgata was determined by scratch assay. 
 Results: Ethyl acetate extract of C. virgata (CVEA) had the highest DPPH radical scavenging activity with a IC50 value of 138.7 μg/mL. On the other hand, hexane (CVH) and aqueous ethanol (CVAE) revealed a very poor antioxidant activity with a IC50 values of 824,8 µg/mL and 610,3 ± 12,8 µg/mL, respectively. According to ABTS results, it was determined that the CVEA extract had stronger radical scavenging activity than the other extracts. On the other hand, among all of the extracts analysed, it was found that phenolic contents of CVEA extract had higher than other extracts. Except for CVAE extract, other extracts showed antiproliferative activity depending on the dose. 
 Conclusion: According to the obtained results, our finding suggests that CVAE extract has a migratory effect on fibroblasts and that CVAE might be a potential therapeutic agent for wound healing.
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