Abstract
Early studies of the interactions of intraocular lens (IOL) implant materials with corneal endothelial cells showed that momentary contact during surgery could result in permanent damage to these cells. It was also demonstrated that this damage could be prevented by providing a protective barrier between the intraocular lens substrate and the endothelium. This barrier might be in the form of a permanent or dissolvable coating, or introduction of a hydrophilic viscoelastic to the anterior chamber of the eye prior to implantation. It is desirable to examine this effect in vitro when developing new IOL materials or surface modifications. The technique developed for this purpose provides an improvement over previous methods, in that momentary contact and the forces involved are computer controlled for consistency, and image analysis may be used in quantifying the amount of damage.The computer controlled test instrument designed and built at IOLAB brings the test material and a rabbit eye corneal endothelial surface into contact with a specified load, time, and stage speed.
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Schedule a callMore From: Proceedings, annual meeting, Electron Microscopy Society of America
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