Abstract
Choroid plexus cysts (CPCs) are often transient and benign findings observed in pregnancy screenings. This study aimed to examine the association between the frequency of congenital heart diseases and the detection of CPCs. In this prospective case-control study, pregnant mothers with no predisposing risk factors for the development of fetal cardiac abnormalities were eligible for entry. Based on the presence or absence of CPCs on ultrasound, the enrolled fetuses were divided into two groups. All patients (n = 100) underwent two-dimensional and color Doppler echocardiography to identify potential cardiac anomalies. Overall, CPCs were detected in 53 enrolled fetuses, and the remainder were enrolled as controls (n = 47). Pathological findings, such as echogenic intracardiac focus (EIF), ductal spasm, atrial septal defect (ASD), pericardial effusion, cardiomyopathy, and congenital heart disease were found in neither group. In the CPC group, two mild and six trivial cases of tricuspid regurgitation (TR) were detected. In the controls, five cases of trivial TR were identified. In conclusion, the presence of CPCs was not associated with significant functional or structural fetal cardiac abnormalities, which may be due to altered developmental mechanisms.
Highlights
Choroid Plexus Cysts (CPCs) refer to small, fluid-filled structures originating from the lateral ventricles of the fetal brain
These cysts result from the accumulation of cerebrospinal fluid (CSF) in the villi and may resolve with increasing gestational age [1]
While some studies recognize no clinical significance for Choroid plexus cysts (CPCs) [4,5], other investigations have reported an association between the presence of these cysts and chromosomal abnormalities: CPCs are found in 53% of trisomy
Summary
Choroid Plexus Cysts (CPCs) refer to small, fluid-filled structures originating from the lateral ventricles of the fetal brain. While some studies recognize no clinical significance for CPCs [4,5], other investigations have reported an association between the presence of these cysts and chromosomal abnormalities: CPCs are found in 53% of trisomy. 18 fetuses on prenatal ultrasound screening [6,7] This has inadvertently raised the concern regarding the development of CPCs and their probable clinical associations. To the best of our knowledge, no previous study has investigated the association between CPCs and the development of fetal cardiac anomalies. To address this issue, we designed and performed this study to evaluate the necessity of fetal heart echocardiography in fetuses with CPCs
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