Abstract
It is an interesting thing to known the effect of natural matter as bee venom as antiviral agent and to any extent it couldbe used in case of experimental rabies infection. In vitro study revealed that different concentrations of bee venom (startedfrom the original concentration “1mg/ml” up to 1:1000) did not show any cell growth retarders or cellular changesshowing normal growth rate and normal cell shape. 1mg/ml and 100μgm/ml of bee venom were able to inhibit thereplication of 100 TCID50 of rabies virus (ERA strain) in using baby hamster kidney BHK cells while 10 and 1μgm/mlwere negative. In vivo study showed that mice received rabies immune globulin and BV were able to withstand the rabisinfection when the they were administrated on the o, 1st, 2nd and 3rd day post infection showing protection rate of 90 and80% respectively but those mice received the treatment on the following days did not survive the infection and showedparalysis of the hind limbs by the 4th day and died by the 6-7th day post infection. It could be concluded that bee venomcould be used in case of rabies infection when administrated on the suitable time post exposure
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