Abstract
The aquatic infectious pancreatic necrosis virus (IPNV) causes a severe disease in farmed salmonid fish that generates great economic losses in the aquaculture industry. In the search for new tools to control the disease, in this paper we show the results obtained from the evaluation of the antiviral effect of [Cu(NN1)2](ClO4) Cu(I) complex, synthesized in our laboratory, where the NN1 ligand is a synthetic derivate of the natural compound coumarin. This complex demonstrated antiviral activity against IPNV at 5.0 and 15.0 µg/mL causing a decrease viral load 99.0% and 99.5%, respectively. The Molecular Docking studies carried out showed that the copper complex would interact with the VP2 protein, specifically in the S domain, altering the process of entry of the virus into the host cell.
Highlights
Aquaculture is an important source of food, nutrition, income, and livelihoods for hundreds of millions of people around the world
We have synthesized a complex [Cu(NN1 )2 ]ClO4, where the NN1 ligand is a synthetic derivate of the natural compound coumarin (NN1 = 6-((quinolin-2-ylmethylene)amino)-2H-chromen-2-one) which showed remarkable antibacterial activity against F. psychrophilum, a pathogen that attacks salmon [20] and in marine bacterium V. harveyi [21]
In this work, we evaluate the antiviral activity of this copper complex against infectious pancreatic necrosis virus (IPNV) and propose that activity would be explained by interactions between protein target of the virus and the metal complex based on molecular docking simulations
Summary
Aquaculture is an important source of food, nutrition, income, and livelihoods for hundreds of millions of people around the world. With intensification of the production, viral diseases have emerged representing a challenge to sustainable development. The aquatic infectious pancreatic necrosis virus (IPNV) causes infectious pancreatic necrosis (IPN), a severe disease in farmed salmonid fish that causes great economic losses in the aquaculture industry. IPNV is among the most persistent salmonid pathogens in Chile [1]. This virus belongs to the genus Aquabirnaviru family Birnaviridae [2]. In addition to the mortality caused directly by viral infection, the virus causes immunosuppression in fish, making them more vulnerable to other pathogens [5]
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