Abstract
Blighia sapida is widely used in traditional medicine for the treatment of several diseases in Togo. This study aimed to assess the antioxidant and anti-inflammatory properties of Blighia sapida. To this end, a phytochemical screening was carried out, followed by an assessment of DPPH, total antioxidant capacity, ex vivo lipoperoxidation tests on Sprague Dawley rats, and an evaluation of anti- inflammatory activity by the egg albumin denaturation test. The leaves extract scavenged the DPPH free radical with an IC50 of 172 ± 0.577µg/mL and its total antioxidant capacity value was 40.174 ± 0.638 mg Eq AA/g. In the ex vivo lipoperoxidation test on the kidney and liver, the extract showed a significant inhibitory effect. Phytochemical tests revealed the presence of tannins, flavonoids, alkaloids, saponosides, and carbohydrate compounds. The present results showed that Blighia sapida leaves possess antioxidant and anti- inflammatory properties which may be linked to the bioactive compounds they contain, suggesting their use to prevent oxidative and inflammatory processes.
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