Abstract
The antidiabetic thiozolidinediones (TZDs) a class of peroxisome proliferators-activated receptor (PPAR) ligands has recently been the focus of much interest for their possible role in regulation of inflammatory response. The present study was designed to evaluate the anti-inflammatory activity of pioglitazone in experimental models of inflammation in rats. The present study was conducted to evaluate the anti inflammatory effect of TZDs (pioglitazone 3mg/Kg) on acute, sub acute and chronic model of inflammation by using egg-albumin and formalin–induced paw edema in 72 rats, relative to reference drugs Dexamethasone 5mg/Kg and Piroxicam 5mg/Kg. In each inflammation model, 24 rats were allocated into four subgroups, each containing six rats representing control, two standards, and test groups. All treatments were given (I.P) 30 minutes before induction of inflammation and the increase in paw edema was measured at certain time intervals by using vernier caliper. Pioglitazone produced nonsignificant reduction (P>0.05) of egg albumin-induced acute inflammation of the rat hind paw, while significantly produced time-related reduction of formalin-induced sub-acute and chronic inflammation of the rat hind paw. In conclusion, pioglitazone possesses anti-inflammatory activity in the animal models of sub-acute and chronic inflammations.
 Key Words: Pioglitazone, PPAR-γ, anti-inflammatory activity
Highlights
IntroductionThe inflammatory process is often viewed as being comprised of three closely linked phases: initiation, propagation and resolution
Inflammation is a complex biological set of interactions between soluble factors and cells that can arise in any tissue due to disturbed homeostasis in response to traumatic, infectious, post-ischemic, toxic or autoimmune injuries [1] .The inflammatory process is often viewed as being comprised of three closely linked phases: initiation, propagation and resolution
The ability of antiinflammatory drug to suppress paw inflammation was expressed as percentage of inhibition of paw edema [16].In formalininduced sub acute inflammation, the test group was treated with pioglitazone 3mg/Kg and the two standard groups were treated with piroxicam 5mg/Kg and dexamethasone 5mg/Kg, while the control group was treated with dimethylsulfoxide 2ml/Kg
Summary
The inflammatory process is often viewed as being comprised of three closely linked phases: initiation, propagation and resolution. It is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue [2]; if the targeted destruction and assisted repair are not properly phased, inflammation can lead to persistent tissue damage contributing to the pathogenesis of common chronic inflammatory diseases such as atherosclerosis, arthritis, inflammatory bowel disease and multiple sclerosis [1,3,4]. The modulatory role of peroxisome proliferator-activated receptors (PPARs) has been proposed in the inflammatory response of different tissues and organs [6] The current antiinflammatory therapies designed to limit or interrupt the synthesis or action of mediators that drive the host's response to injury i.e. limit the initiation and propagation phases [2].
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Schedule a callMore From: Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512)
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