Abstract
Diabetes mellitus (DM) is a serious chronic degenerative disease characterized by high levels of glucose in the blood. It is associated with an absolute or relative deficiency in the production and/or action of insulin. Some of the complications associated with DM are heart disease, retinopathy, kidney disease, and neuropathy; therefore, new natural alternatives are being sought to control the disease. In this work, we evaluate the antidiabetic effect of Spondias purpurea seed methanol extract (CSM) in vitro and in a glucose-induced diabetic zebrafish model. CSM is capable of lowering blood glucose and cholesterol levels, as well as forming advanced glycation end-products, while not presenting toxic effects at the concentrations evaluated. These data show that CSM has a promising antidiabetic effect and may be useful in reducing some of the pathologies associated with diabetes mellitus.
Highlights
Excess glucose in the blood results in the development of reactive oxygen species [4], inducing the proliferation of oxidative stress [5], which induces the formation of advanced glycation end products (AGEs) [6], the development of dyslipidemia [7], as well as a series of metabolic disorders linked to the disease
The objective of this study is to evaluate the effect of the methanol extract from S. purpurea (CSM) seeds on the regulation of blood glucose, triglyceride, and cholesterol levels, as well as to determine whether the extract is capable of inhibiting the protein glycation reaction using a glucose-induced diabetic zebrafish model
The methanol extract from S. purpurea (CSM) seeds is effective in reducing blood glucose, hypercholesterolemia, and advanced glycation end products
Summary
DM is a chronic-degenerative disease related to elevated blood sugar levels; this causes damage to cells, organs, and systems [3]. Excess glucose in the blood results in the development of reactive oxygen species [4], inducing the proliferation of oxidative stress [5], which induces the formation of advanced glycation end products (AGEs) [6], the development of dyslipidemia [7], as well as a series of metabolic disorders linked to the disease. There are different types of diabetes, including type 1 diabetes (DM1), which is caused by insulin dependence. There is type 2 diabetes (DM2), which is the most predominant and is related to the increase in glucose concentration and insulin resistance or sensitivity [8]
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