EVALUATION OF THE ANTIBACTERIAL EFFICACY OF USING A BONE ALLOGRAFT DEVELOPED ACCORDING TO THE MARBURG SYSTEM OF BONE BANK ON A MODEL OF CHRONIC OSTEOMYELITIS

Abstract

Bone infections due to fractures or implants are a big medical problem. In experimental medicine, many experimental models have been created on different animal species to simulate the disease condition and to do experience treatments. The aim of this paper was to present an antibacterial efficacy of using a bone allograft developed according to the Marburg system of bone bank on a model of chronic osteomyelitis induced in rabbits.In research was used 54 rabbits. Osteomyelitis was induced in rabbits by a human strain of St. aureus ATCC 43300, in the rabbit femur. There have been created 3 groups of animals. In 1st group used antibiotic impregnated biodegradable material “PerOssal”. In 2nd group used antibiotic impregnated whole bone allograft. In 3rd group used antibiotic impregnated perforated bone allograft. Evaluation of installation and evolution of the disease was done by microbiological. A separate study of microbiological data is presented here.This study showed, in the 1st and 3rd groups there is a persistent decrease in CFU by 14 knocks to 120.4 in the 1st group and to 3.5 in the 3rd group, and in the 2nd group, on the contrary, there is an increase in CFU to 237.33. This shows the lack of effectiveness of using a whole bone allograft.The results showed, after 7 days there was no statistically significant difference between the groups. After 14 days the perforated bone allograft impregnated with antibiotic was better than the biodegradable material “PerOssal”.